🧬Supplements in Focus

Recent studies underscore the evolving role of dietary supplements in clinical treatments. A promising double-blind, randomized trial has demonstrated that curcumin supplementation
significantly enhances outcomes for patients with diabetes and atherosclerotic cardiovascular risk by mitigating inflammation linked to chronic conditions such as hypertension. Additionally, research indicates that curcumin, when combined with high-content eicosapentaenoic acid, may improve metabolic indices in ischemic stroke rehabilitation patients. This showcases curcumin's potential in addressing multifaceted inflammatory responses.

Moreover, Viridian Therapeutics is at the forefront of advancing innovative treatments with veligrotug, which aims to become the preferred intravenous treatment for thyroid eye disease (TED), subject to forthcoming clinical data. These studies illustrate the efficacy of supplements like curcumin in managing complex conditions, reinforcing their potential in clinical practice and highlighting the need for further exploration by healthcare providers.

Sources:
Scientific Reports - Study on Curcumin and Inflammation

BioSpace - Viridian Therapeutics Progress Report

Advising patients about supplements necessitates meticulous examination of safety, efficacy, and potential interactions with prescribed medications. A comprehensive medication review is vital, as certain supplements may interact adversely with conventional drugs, impacting therapeutic results. For example, supplements like St. John's Wort can alter the metabolism of various medications, including antidepressants and anticoagulants, which may lead to reduced drug effectiveness or heightened side effects.

When recommending supplements, it is crucial to discuss evidence-based benefits and appropriate dosages. Healthcare providers can utilize tools such as MedSafer software to identify and deprescribe unnecessary medications, particularly in senior patients, whose
supplement use may complicate their clinical profiles. Furthermore, it is important to educate patients about specific timing protocols; for instance, a four-hour separation is recommended between levothyroxine and dairy products to ensure optimal absorption.

By fostering a collaborative dialogue with patients on their supplement use, physicians can enhance safety and therapeutic efficacy, ultimately leading to improved health outcomes.

Sources:
EatingWell - Supplements to Consider for High Cholesterol

ScienceDaily - New MedSafer Software for Medication Management

EatingWell - Medications That Don’t Mix Well With Dairy

Managing specific health conditions with the use of dietary supplements can prove beneficial. Here are some key recommendations:

High Cholesterol
Supplements such as plant sterols and omega-3 fatty acids are effective in lowering cholesterol levels. Plant sterols can notably reduce LDL cholesterol levels when consumed with meals, while omega-3 fatty acids have been shown to improve heart health and lower triglycerides. Additionally, soluble fiber supplements like psyllium can play a role in cholesterol management.

Sleep Disorders
For enhancing sleep quality, magnesium, 5-HTP, and passionflower extract are highly recommended. Magnesium has been found to improve sleep quality and alleviate anxiety, while 5-HTP can assist in sleep latency and promote restorative sleep stages. Passionflower extract may also enhance deep sleep when ingested 30-90 minutes before bedtime.

Gastrointestinal Issues
Probiotics, magnesium oxide, and polyethylene glycol are advisable for maintaining gastrointestinal health. Probiotics support gut health and restore balance, while magnesium oxide helps relieve constipation by drawing water into the intestines. Polyethylene glycol is effective for easing difficulties in bowel movements.

Incorporating the right supplements may significantly support the management of these health issues. Always consult with a healthcare professional before starting any new supplement regimen.

Sources:
EatingWell - Supplements to Consider for High Cholesterol

Best Life - Best Supplements for Sleep

PennLive - Adding This One Inexpensive Supplement

EatingWell - Supplements That Can Help Relieve Constipation

This episode features Dr. David Sinclair diving deep into the epigenetic mechanisms behind aging, the science of resetting biological clocks, and how lifestyle, supplements, and epigenetic therapies are changing the game in longevity. A powerful listen between patients — because understanding the biology is where practical intervention begins.

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